Editing repeats in Huntington’s:fewer somatic repeat expansions in patient cells
Abstract Trinucleotide repeat (TNR) diseases are neurological disorders caused by expanded genomic TNRs that become unstable in a length-dependent manner. The CAG•CTG sequence is found in approximately one-third of pathogenic TNR loci, including the HTT gene that causes Huntington’s disease. Friedreich’s ataxia, the most prevalent hereditary ataxia, results from GAA repeat expansion at the FXN […]
Pyrefly vs. Ty: Comparing Python’s Two New Rust-Based Type Checkers
Note: I like using em-dashes while writing! Don’t worry, this is not written by AI. (context) Earlier this month, two new Rust-based Python type checkers hit the spotlight: pyrefly and ty. Although neither is officially released, they are a welcome change to the Python type checking world, historically dominated by mypy and pylance. While both […]
Show HN: Malai – securely share local TCP services (database/SSH) with others
Introducing Malai TCP & A Bonus! malai-0.2.5 is out now! It brings a new feature to share your local TCP server with the world! Now you can share any TCP-based service running locally — including your SSH service, Postgres database, Redis, or even a custom TCP protocol — using the same seamless workflow that you […]
Mistral Agents API
Today we announce our new Agents API, a major step forward in making AI more capable, useful, and an active problem-solver. Traditional language models excel at generating text but are limited in their ability to perform actions or maintain context. Our new Agents API addresses these limitations by combining Mistral’s powerful language models with: Built-in […]
Why Cline Doesn’t Index Your Codebase (and Why That’s a Good Thing)
Here’s a common question we get from prospective Cline users: “How does Cline handle large codebases? Do you use RAG to index everything?” It’s a reasonable question. Retrieval Augmented Generation (RAG) has become the go-to solution for giving AI systems access to large knowledge bases. But for Cline, we’ve taken a deliberately different path. We […]
DuckLake is an integrated data lake and catalog format
DuckLake provides a lightweight one-stop solution for if you need a data lake and catalog. You can use DuckLake for a “multiplayer DuckDB” setup with multiple DuckDB instances reading and writing the same dataset – a concurrency model not supported by vanilla DuckDB. If you only use DuckDB for both your DuckLake entry point and […]
Outcome-Based Reinforcement Learning to Predict the Future
Abstract:Reinforcement learning with verifiable rewards (RLVR) has boosted math and coding in large language models, yet there has been little effort to extend RLVR into messier, real-world domains like forecasting. One sticking point is that outcome-based reinforcement learning for forecasting must learn from binary, delayed, and noisy rewards, a regime where standard fine-tuning is brittle. […]
The Art of Fugue – Contrapunctus I (2021)
JS Bach’s last set of works, collectively titled The Art of Fugue, was published shortly after his death. It was not a big hit. Dense counterpoint was deeply unfashionable at that time, as Western European aristocratic tastes shifted toward singable melodies over block chords. The first published edition of The Art of Fugue only sold […]
How a hawk learned to use traffic signals to hunt more successfully
Adult Cooper’s hawk dispatching a house sparrow. Image: Vladimir Dinets. Dr Vladimir Dinets, a research assistant professor at the University of Tennessee, is a zoologist who studies animal behavior, ecology, and conservation. As of 2025, he also teaches mathematics at Rudgers University. He is the author of a recently published Frontiers in Ethology article that […]
BGP handling bug causes widespread internet routing instability
May 27 2025 At 7AM (UTC) on Wednesday May 20th 2025 a BGP message was propagated that triggered surprising (to many) behaviours with two major BGP implementations that are often used for carrying internet traffic. This caused a large number of “internet facing” BGP sessions to automatically shut down, causing at the very least some […]